After saving the universe for a second time in Ratchet and Clank: Going Commando, our two heroes have returned to the easy life. Riding their wave of popularity, the duo even managed to snag themselves a TV show. However, after weeks of product testing, it was discovered that Clank's charm was what everyone really wanted -- making him the star of the show and sticking Ratchet in a cameo role which are usually reserved for B-list actors or Mark Hamill. Things soon change when Dr. Nefarious returns with his new plan to destroy all organic life in the universe. In response, the galactic president sends out a call for the man who defeated the good doctor last time, a call that throws Ratchet and Clank back into the action.